The need for alternatives to antibiotics in the fight against infectious diseases has inspired scientists to focus on antivirulence factors instead of the microorganisms themselves.In this respect, prior work indicates that tiny, enclosed bilayer lipid membranes (liposomes) have the potential to compete with cellular targets for toxin binding, henc

Immune checkpoint blockade (ICB) has changed the therapeutic landscape of oncology but its impact is limited by primary or secondary resistance.ICB resistance has been related to a lack of T cells infiltrating into the tumor.Strategies to overcome this hurdle have so far focused on the tumor microenvironment, but have mostly overlooked the role of

Abstract Background Organisms use highly accurate molecular processes to transcribe their genes and a variety of mRNA quality control and ribosome proofreading mechanisms to maintain intact the fidelity of genetic information flow.Despite this, low level gene translational errors induced by mutations and environmental factors cause neurodegeneratio

The criminal act of corruption, defined as the abuse of power for personal gain, is essentially a matter of social injustice.Corruption is considered an extraordinary crime because it is carried out in a systematic way, and the impact caused might adversely affect the economic life and national development.For this reason, handling cases of corrupt